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As a result, the expression patterns of Id2 and Ids were investigated by immunocytochemistry in developing and adult vibrissae. Wistar rats aged E14toP4 were used to cover all stages of vibrissae development (stages 0 6+) and 3 6 month old rats for the adult stages. This thesis reports that high Id2 expression was seen in specialised neuroendocrine cells (Merkel cells) of the hair follicle and basal epidermis, confirmed by co expression of the Merkel cell marker side effects of steroids, cytokeratin 20.

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side effects of steroids There is no cure. Treatments help, but can only improve the appearance, not eliminate the cause. One which may restore a resemblance of normal pigment is topical steroid therapy. Using high density microarray analysis of the cell transcritptome we have identified those genes and proteins most sensitive to glucose and fatty acid environment. Our data shows that of those potentially able to activate STAT1 or NF B pathways, TNFR5 is the most highly upregulated by glucolipotoxicity. Importantly our data also shows that the physiological ligand for TNFR5 side effects of steroids, CD40L, elicits NF B activity in cells, whereas selective knock down of TNFR5 ameliorates glucolipotoxic induction of STAT1 expression and NF B activity. side effects of steroids

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